Recent Tools and Software for Computer Aided Drug Design

Abstract

The drug discovery process in the modern era is characterized by synthesis of large number of compounds and the examination of these molecules in a short period of time, making the drug discovery process very expensive, challenging and time consuming. This has given rise to a very important technique known as computer aided drug design (CADD) in the last few years. This technique is used in the various stages of drug discovery such as the target identification, hit identification, lead generation and optimization. In this review project, we presented the brief review of CADD. We presented wide range of approaches and methodologies such as chemoinformatics, bioinformatics, ADMET parameters, pharmacophore modeling, docking, drug repurposing and their application in various stages drug discovery and development process. This review also provides an insight about recent commercial and freeware tools and software used for each CADD approaches. In addition, proper implementation of these tools could reduce the cost of drug designing and development.