An Overview of Formulations for the Treatment of Pulmonary Fibrosis

Abstract

Through this report, an effort is made to understand and explain the disease - ‘Idiopathic Pulmonary Fibrosis’. A study on the basic lung anatomy and physiology is carried out and the various targeted treatment techniques like Aerosol Therapy and the instruments used to administer it are discussed to set the foundation of the study. Various lung disorders like- Covid-19, COPD, Lung Cancer, and Asthma along with their pathophysiology and treatments are discussed. The symptoms, causes and the progression of the disease ‘Idiopathic Pulmonary Fibrosis’ is explainedalongwith the treatments that are currently used. A detailed account of the medicaments i.e. Pirfenidone and Nintedanib preferred today is mentioned. Since, these medicaments do not provide a permanent cure for the disease and only help in slowing the progression of the disease for a few years, it is imminent to discover new treatment techniques. A history of previous trials conducted for the same has been provided along with the grounds for their failure. Drugs like Azathioprine, Warfarin, Cyclophosphamide, Bosentan and many others were considered and rejected. Lastly, a comparison has been drawn with the other fibrotic disorders of the human body with Pulmonary Fibrosis and an attempt has been made to alterthe course oftreatment of the disease forthe better.