Development, Optimization and Charecterization of Microemulsion Based Gel Using Ectoin for Management of Atopic Dermatitis

Abstract

Atopic dermatitis is a very relapsing, chronic, itchy and inflammatory topical disease that generally affecting infants and small children as well as adults. The main symptoms of dermatitis are red itchy skin generally inflammation which turns into eczema. The main triggers of dermatitis are allergens, infection, stress, heat and sweating. Generally topical corticosteroids are used for treatment of atopic dermatitis and also topical calcineurine inhibitor used. But these cause harmful side effects. Ectoin is a natural active that obtain from bacteria and it is a natural stress protect molecule that used in atopic dermatitis. The objective of preparation of microemulgel is to increase permeation. This is used as permeation enhancer. Gel gives ease of use of formulation on skin. There are advantages of preparing microemulgel because it increases penetration also give stability and reduces stickiness. Currently only cream of ectoin available in market. Ectoin also used in cosmetic industry. The main objective of this thesis is to formulate dosage form that having good penetration and better efficacy for treatment of atopic dermatitis. Spontaneous emulsification method used for preparation of micro emulsion. Jojoba oil used as oil phase, simulsol 1293 used as surfactant and polyethylene glycol 400 used as co surfactant. Carbopol or xanthan gum used as gelling agent. The formulation was evaluated for viscosity, pH, particle size, zeta potential, and In vitro release. In this formulation, harmful parabans are not used. Prepared 1% ectoin emulgel gives good result in drug release, appearance, texture and viscosity