DMBA- Induced Breast Cancer: A Hormonal Camouflage

Abstract

Background: Breast cancer is one of the high prevalence cancers worldwide af fecting women based on various factors. Hormonal changes are amongst the factors in volved in the development of breast cancer. The basic hormones involved include estrogen and progesterone with human epidermal receptor-2 (HER2) which could be either over expressed or not at all expressed. Therefore, studies were conducted on the DMBA induced breast cancer model. Methods: As per literature review, there has been complete befuddlement on the hormonal crisis of the DMBA induced model hence we performed the immunohistochemistry studies of estrogen, progesterone and human epidermal receptor-2 in order to prove the presence or absence of the major hormones involved in progression of breast cancer. Preceding morphological tumor detection, it was further confirmed with hematoxylin-eosin stained sections. Results: These data initially detected the probable presence of mucin in the hematoxylin eosin stain hence we performed specific mucin stain using Meyer’s mucincarmine con cluding mucinous carcinoma. Thereafter, we obtained negative estrogen and HER2, with positive progesterone in the immunohistochemistry studies. Conclusion: Conclusively, DMBA induced breast cancer is a suitable model for mucinous carcinoma in estrogen and human epidermal receptor-2 negative and progesterone positive breast cancer.