Preliminary Investigation for A Potential Ameliorative Role of Methanolic Extract of Leaves of Polyalthia longifolia and Trigonella foenum and Seeds of Murraya koenigii on Lindane Treated Male Rats

Abstract

Lindane is reported have to detrimental effects on different tissues. In the present study the 90 male Albino Swiss rats were treated lindane at a dosage of 250ppm/kg body weight/day. Following the lindane treatment, shrinkage in the testis was observed but there was no physiological difference in complete body mass. Sperm production was also hampered and the generated sperms were also damaged. Profound histological changes were also observed in the testis and degeneration of the Leydig cells was noted along with reduction in serum testosterone levels. Oxidative stress was also observed to ascent during the lindane treatment course revealing significant generation of ROS. Following the plant extract treatment a significant recovery was observed. The fertility of the rats was restored whereas the functioning of the reproductive organs and accessory sex organs were also apt almost comparable to that of the control group. ROS generation was also observed to decline following the plant extract treatment