IR @ Nirma University
Keeping in tune the global developments we are creating an institutional repository using DSpace Software (Digital Library Software). We are archiving institutional knowledge like, faculty papers, theses, and dissertations in PDF format at DSpace. Students can access this digital information anywhere in the campus.
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http://10.1.7.192:80/jspui/handle/123456789/2535| Title: | Synthesis and biological evaluation of some 5-ethoxycarbonyl-6- isopropylamino-4-(substitutedphenyl)aminopyrimidines as potent analgesic and anti-inflammatory agents |
| Authors: | Chhabria, Mahesh T. Bhatt, Hardik G. Raval, Hitesh G. Oza, Pratik M. |
| Keywords: | Aminopyrimidines Analgesic Anti-inflammatory Cyclooxygenase NSAIDs Facuty Paper Pharmacy Faculty Paper IPFP0022 |
| Issue Date: | 2007 |
| Publisher: | Elsevier Publication |
| Series/Report no.: | IPFP0022 |
| Abstract: | Synthesis and biological evaluation of some 5-ethoxycarbonyl-6-isopropylamino-4-(substitutedphenyl)aminopyrimidines have been achieved by cyclization of N-[2-ethoxycarbonyl-2-cyano-1-(isopropylamino)vinyl] formamidine in presence of dry HCl in dioxane followed by nucleophilic substitution of 4-chloro group with substituted aromatic amine or phenoxide. Target compounds were evaluated for their analgesic and anti-inflammatory potential by known experimental models. Some of the compounds emerged out as more potent than standard drugs. Very low ulcer index was observed for the potent compounds.2006 Elsevier Ltd. All rights reserved. |
| Description: | Bioorganic & Medicinal Chemistry Letters 17 (2007) 1022–1024 |
| URI: | http://hdl.handle.net/123456789/2535 |
| Appears in Collections: | Faculty Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IPFP0022.pdf | IPFP0022 | 116.77 kB | Adobe PDF |  View/Open |
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