Development Of Controlled Porosity Osmotic Pump Of Metoprolol Succinate: Design, Optimization And Characterization

Abstract

Controlled porosity osmotic pump (CPOP) drug delivery system is a dosage form which follows a zero order release and provide a controlled release for a long duration and makes it one of the most promising drug delivery systems in the recent times. In this study, a cardioselective β1-adrenergic blocking agent, Metoprolol Succinate is used as the drug of choice for the formulation, development and evaluation of the CPOP using two different osmogens viz. Sodium Chloride and Potassium Chloride, at three different ratios and three different concentrations of cellulose acetate coating as the semi permeable agent. Polyethylene Glycol 4000 was used as a plasticizer and Sorbitol was used as a pore forming agent. Drug release profile of the batches and burst strength of the exhausted shells were evaluated for the optimization of the formulations and these optimized formulations were studied for the effect of pH, agitational intensity and osmotic pressure. A comparative study between various osmogens was also done. The drug release profiles of all the batches were compared with marketed product-Seloken. A 32 Full Factorial Design using Statistica Software version 9.0 was applied on the batches to get the optimized result. Dissolution data of optimized formulation was fitted to various mathematical models to describe kinetics of drug release.