Upscaling of Longifolene Isomerization In Continuous Flow Reactor Over Solid Acid Catalyst

Abstract

Isomerization, is the chemical process by which a compound is transformed into any of its isomeric forms & Longifolene is the common (or trivial) chemical name of a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins. Isomerization of longifolene with solid acid catalyst such as sulfated zirconia gives Isolongifolene. Isolongifolene and its derivatives, which extensively used in prefumery industry due to their woody and floral odor. The acid catalysed and hydroformylated products of this isomerized isolongifolene have also woody amber odor and are used as a flavor in many pharmacutical industries. Isomerisation of longifolene with nano-crystalline sulphated zirconia (SZ) solid acid catalyst and obtained 95-97% conversion of longifolene and 100% selectivity of isolongifolene at 180°C within 15-30 minutes under stirred batch reactor. It is noteworthy that SZ exhibited similar catalytic activity over a wide range of longifolene to SZ weight ratio, i.e.,10:1 to 100:1. The acid catalysed and hydroformylated products of this isomerized isolongifolene have also woody amber odor and are used as a flavor in many pharmacutical industries. isomerisation of longifolene with nano-crystalline sulphated zirconia (SZ) solid acid catalyst and obtained 95-97% conversion of longifolene and 100% selectivity of isolongifolene at 180°C within 15-30 minutes under stirred batch reactor. It is noteworthy that SZ exhibited similar catalytic activity over a wide range of longifolene to SZ weight ratio, i.e., 10:1 to 100:1. so now for industrial production of isologifolene we need to upscaling this process by using the continuous flow fixed bed reactor.so we transfer this isomerization process lab scale to industrial scale. The up scaling of the process for the said reaction will be carried out in continuous flow reactor: so in this upscaling we Design and modification of existing continuous flow reactor. we also study Different forms of the catalyst such as beads, granules and powder studied using different binders and their effect on the activity and life of the catalyst and we also study the Various reaction parameters such as temperature, time and substrate to catalyst weight ratio. so and optimized this parameters we can get the achieve maximum conversion and selective formation of the product from lab scale to large scale.