Optimization And Characterization Of Rapidly Dissolving Films Of Cetirizine Hydrochloride Using Cyclodextrins For Taste Masking

Abstract

Cyclodextrin and its derivatives were used as taste masking agents for the preparation of rapidly dissolving films of Cetirizine hydrochloride. The films were evaluated for drug content, thickness, tensile strength, % elongation and elastic modulus, in-vitro and in-vivo disintegration studies, in-vitro dissolution studies and surface morphology. The films were also tested for complex formation using Differential scanning calorimetry and X ray diffraction study. A 32 full factorial design was utilized to study the effect of 2 independent variables i.e. amount of HPMC E3 LV (X1) and amount of PEG 400 (X2) on responses in-vitro disintegration time and mechanical properties. Optimized batch A1 possessed in-vitro disintegration time 67.5 s, 17.7 N/mm2 tensile strength, 50.2 % elongation and 274.2 N/mm2 elastic modulus.