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http://10.1.7.192:80/jspui/handle/123456789/8303| Title: | 28-Days Sub-acute Toxicity Profile of Ethanolicextract of Nyctanthes arbor-tristis Calyx in Rats |
| Authors: | Pawar, N. Gadgoli, C. Kamble, M. Panchal, S. |
| Keywords: | Nyctanthesarbour-tristis Sub-acutetoxicity Carotenoids OECDno.407 OECDno.425 |
| Issue Date: | 2016 |
| Publisher: | PharmacologyOnLine |
| Series/Report no.: | IPFP0311; |
| Abstract: | Nyctanthesarbour-tristis(NAT),Oleaceae,isoneofthemostpopularmedicinalplantinAyurvedicandHomeopathicSystemsofIndianmedicine.NATflowerspossessmultiplepharmacologicalactivitiesanditscalyxisreportedtopossesscarotenoidswhichisresponsibleforrenderingallitsmedicinalproperties.TherationalebehindpresentstudyinvolvesNATflowersconsumptionforvariousmedicinalutilitiesandcommonlyasafoodingredientwithoutanyinformationaboutitsassociatedrisks.Thereforeforthepresentstudy,OECDguidelineno.407of28dayssub-acutetoxicitystudywasfollowedcriticallybyusing48wistarratsofeithersex(24maleand24female).Thedoserangeof250,500and750mg/kgbodyweightofNATextractwasselectedbasedonpreliminarydosedeterminationexperimentsandadministeredbyoralgavagetotherespectivegroups.NATcalyxextracttreatmentinducedsignificantalterationsinessentialhaematologicalparameterslikeRBCs,MCV,MCHCandPlateletsinatleastonetreatedgrouptherebyindicatingitstoxiceffectonhaematologicalsystemaftertheexposurefor28days.ALTlevelsweresignificantlyincreasedbyNATtreatmentsuggestingitspossiblehepatotoxicnatureafterexposurefor28days.Mortalityoffouranimalsfromtreatedgroupswasrecordedattheintermediatestageofthestudy.Hence,cautionshouldbeexercisedwithNATcalyxtreatmentattheconcentrationof250mg/kgbwandabove,whenrequiredtobeconsumedfortheperiodgreaterthan14days. |
| Description: | Pharmacology Online, 2016 Vol. 2: 163-174 |
| URI: | http://10.1.7.192:80/jspui/handle/123456789/8303 |
| Appears in Collections: | Faculty Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IPFP0311.pdf | IPFP0311 | 1.03 MB | Adobe PDF |  View/Open |
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