To Formulation and Characterize Nanoemulgel Containing Anti-Acne Agent (DAPSONE)

Abstract

Acne is a very common inflammatory disorder mostly occurred in teenagers. Main reasons behind inflammation are overproduction of sebum, hormonal changes, bacteria infection, etc. Topical products are the first choice of healthcare practitioners to treat the acne because of some advantages like easy to apply, local action, fewer side effects, etc. Dapsone is the sulfone based antibiotic and has an antibacterial activity with minimum side effects. Currently, two different strengths of Dapsone 5% and 7.5% gel are available in the market. Dapsone has a log P value near to 1; it is less lipophilic so facing difficulties during penetration. Preparation of Nanoemulgel is a convincing concept to improve the penetrability of Dapsone. Nanoemulgel is a combination of Nano emulsion and gel. In which drug is incorporated in the Nano emulsion by preparing o/w emulsion, while gel phase mostly provides proper consistency for the easy application on the face. There are some advantages for preparing Nanoemulgel like increase the drug penetration because of oil droplets acts as lipidic carriers and can incorporate a large amount of drug compared to other nano systems. The main objective of this thesis is to formulate dosage form that has good penetration and better efficacy in the treatment of acne. Spontaneous emulsification method was used to prepare Nano emulsion. While triacetin used as oil phase, labrasol as surfactant and two different co-surfactant transcutol & Tween 80 was used in formulation development while Carbopol 934 was used as a gelling agent. The formulation was evaluated in viscosity, drug content, in-vitro release and ex-vivo release profile