Development and Optimization of Trans-dermal Formulations of Diclofenac sodium

Abstract

The mainpurpose of this study was development and evaluation of the topical formulations that is gels and creams using the gelling agents like Carbopol and HPMC in two different ratios and two different bases for the cream that is bees wax and stearic acid. The drug which was chosen was Diclofenac Sodium which is a NSAIS and mostly used as analgesic. All the prepared formulations of gels and creams were tested and evaluation tests for physical appearance, stability, drug content were performed and all the formulations showed acceptable characteristics. The drug release of all the prepared batches were carried out by an apparatus called as Franz Diffusion cell. The optimized batch was obtained from the results of the evaluation tests and were further validated for its rheological properties.